Ozempic 0.25mg
This page is about the Ozempic injection, given once weekly. Ozempic is also available as a tablet taken once daily in different strengths (1.5 mg, 4 mg and 9 mg), and the two are not interchangeable milligram for milligram. Check whether you were dispensed a pen or a bottle of tablets before following any dosing schedule.
Ozempic 0.25mg is the recommended starting dose for most patients beginning semaglutide therapy. This introductory dose allows your body to gradually adjust to the medication while minimizing gastrointestinal side effects. Most prescribers keep patients at 0.25mg for the first four weeks before increasing.
Dose at a Glance
- Generic Name
- semaglutide
- Dose
- 0.25mg
- Frequency
- Once weekly (injection)
- Half-Life
- ~7 days
- Typical Duration
- 4 weeks
- Dose Type
- Starting dose
What to Expect on Ozempic 0.25mg
- •Mild appetite suppression that may start within the first week or two
- •Some reduction in "food noise" or constant thoughts about eating
- •Possible mild nausea, especially in the first few days after injection
- •Minimal weight loss at this dose, as it is primarily for adjustment
- •Your body building tolerance to semaglutide before dose escalation
Common Side Effects
- •Mild nausea (most common, usually improves within days)
- •Decreased appetite
- •Stomach discomfort or bloating
- •Constipation or diarrhea
- •Fatigue during the first week
Ozempic 0.25mg: Pen and Supply
- How it comes
- Single-patient-use pen (multiple weekly doses)
- Doses per device
- 4 doses of 0.25 mg, then 2 doses of 0.5 mg
- Total strength per volume
- 2 mg / 3 mL
- Concentration
- 0.68 mg/mL
The same 2 mg / 3 mL pen also delivers 0.5 mg doses — 0.25 mg and 0.5 mg are two settings on one device, not two different pens.
Also available as
- Single-dose prefilled syringe, 0.25 mg / 0.5 mL
Source: Ozempic prescribing information, section 3 (label effective 2026-07-30). Presentations available in your country or from your pharmacy may differ — check the carton you are dispensed.
Where This Dose Fits in Titration
The 0.25mg dose is the very first step in the Ozempic titration schedule. It is not intended as a therapeutic dose for blood sugar control or weight loss; rather, it helps your GI system adapt to semaglutide. After 4 weeks, your provider will typically increase you to 0.5mg.
Tips for Ozempic 0.25mg
Take your injection on the same day each week to build a consistent routine
Eat smaller, more frequent meals to help manage any nausea
Stay well hydrated, especially in the first few days after each injection
Keep a symptom journal in JellyPal to share patterns with your doctor
Explore Other Ozempic Doses
Track Your Ozempic 0.25mg Doses
Log every injection, visualize your medication levels with our PK plotter, track side effects, and see a countdown to your next dose. JellyPal supports all Ozempic (semaglutide) dose levels.
View Ozempic TrackerThis page is for informational purposes only and is not medical advice. It does not recommend or adjust any dose. Ozempic (semaglutide) is a prescription medication that should only be used under the supervision of a qualified healthcare provider. Never start, stop, or change your dose without first talking to your doctor.
Frequently Asked Questions
Track your dose with confidence.
Stay on top of your Ozempic journey with injection logging, level tracking, and side-effect insights you can share with your doctor.
